Article
Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination.
Journal of neuropathology and experimental neurology - 1 Aug 2006
Schwindt Heinrich, Akasaka Takashi, Zühlke-Jenisch Reina, Hans Volkmar, Schaller Carlo, Klapper Wolfram, Dyer Martin J S, Siebert Reiner, Deckert Martina
Abstract excerpt
Primary central nervous system lymphomas (PCNSLs) are diffuse large B cell lymphomas confined to the brain. Only minimal data exist on chromosomal aberrations underlying PCNSLs. We studied 41 PCNSLs by fluorescence in situ hybridization for breakpoints affecting the BCL6 locus in chromosomal band...
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