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Article

Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication.

Nature - 25 Jan 2018

Dai Xinghong, Gong Danyang, Lim Hanyoung, Jih Jonathan, Wu Ting-Ting, Sun Ren, Zhou Z Hong

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) causes Kaposi's sarcoma, a cancer that commonly affects patients with AIDS and which is endemic in sub-Saharan Africa. The KSHV capsid is highly pressurized by its double-stranded DNA genome, as are the capsids of the eight other human herpesviruses. Capsid assembly and genome packaging of herpesviruses are prone to interruption and can therefore be targeted for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29342139
DOI: 10.1038/nature25438
PMCID: PMC6039102

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