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Article

The D-domain of Sp3 modulates its protein levels and activation of the p21(CIP1/WAF1) promoter.

Biochemical and biophysical research communications - 23 Sept 2005

Hammill Deborah, Jain Nidhi, Armstrong Susan, Mueller Christopher R

Abstract excerpt

A variety of signals result in the transcriptional induction of the p21(CIP1/WAF1) promoter and both Sp1 and the related Sp3 proteins have been implicated in this induction. We have characterized the role of the C-terminal D-domains of both Sp1 and Sp3 proteins in the activation of this promoter in response to butyrate treatment of Hep G2 cells. We have defined a negative regulatory domain present in the...

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Identifiers

PMID: 16081043
DOI: 10.1016/j.bbrc.2005.07.084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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