Ammonium Induces Aberrant Blastocyst Differentiation, Metabolism, pH Regulation, Gene Expression and Subsequently Alters Fetal Development in the Mouse

Abstract excerpt

The presence of ammonium in the culture medium has significant detrimental effects on the regulation of embryo physiology and genetics. Ammonium levels build up linearly over time in the culture medium when media containing amino acids are incubated at 37 degrees C. Ammonium in the culture media significantly reduces blastocyst cell number, decreases inner cell mass development, increases apoptosis, perturbs...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Prenatal Screening and Diagnostics
• Share to Renal and related cancers
• Share to Reproductive Biology and Fertility