Article
Low intracellular pH is involved in the early embryonic death of DDK mouse eggs fertilized by alien sperm.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 1994
Leclerc C, Becker D, Buehr M, Warner A
Abstract excerpt
Intracellular pH was measured in normal 8-cell stage mouse embryos and in embryos from a cross between DDK females and C3H males. DDK/C3H embryos display the DDK syndrome and spontaneously begin to decompact toward the late 16-cell stage. Ultimately, 90% fail to form blastocysts. Normal embryos h...
Topics
- Animals
- Blastocyst
- Bucladesine
- Cell Communication
- Cell Death
- Crosses, Genetic
- Cyclic AMP
- Female
- Fertilization
- Gap Junctions
- Hydrogen-Ion Concentration
- Male