Article
Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein.
Circulation - 17 Jun 2003
Bisoendial Radjesh J, Hovingh G Kees, Levels Johannes H M, Lerch Peter G, Andresen Irmgard, Hayden Michael R, Kastelein John J P, Stroes Erik S G
Abstract excerpt
BACKGROUND: Loss-of-function mutations in the ATP-binding cassette (ABCA)-1 gene locus are the underlying cause for familial hypoalphalipoproteinemia, providing a human isolated low-HDL model. In these familial hypoalphalipoproteinemia subjects, we evaluated the impact of isolated low HDL on endothelial function and the vascular effects of an acute increase in HDL. METHODS AND RESULTS: In 9 ABCA1 heterozygotes...
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