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Article

[The role of mtDNA deletion in the sensitivity to aminoglycoside antibiotic induced deafness].

Zhonghua er bi yan hou ke za zhi - 1 Apr 2000

Kong W, Liu J, Dong J

Abstract excerpt

OBJECTIVE: To establish an animal model of mitochondrial DNA (mtDNA) deletion and investigate the possible role of mtDNA deletion in aminoglycoside antibiotic induced deafness. METHODS: Thirty wistar rats (4 months) were randomly divided into group A and B. Doxorubicin (DOX) was subcutaneously injected at doses of 2 mg/kg twice per week for 3 months in group A and then kanamycin (KM) was intraperitoneally...

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PMID: 12768661

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ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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