Article
Audiological and genetic features of the mtDNA mutations.
Acta oto-laryngologica - 1 Jul 2008
Liu X Z, Angeli S, Ouyang X M, Liu W, Ke X M, Liu Y H, Liu S X, Du L L, Deng X W, Yuan H, Yan D
Abstract excerpt
CONCLUSIONS: Significant difference in the incidence of mitochondrial DNA (mtDNA) mutations was found between the Chinese and USA populations. The identification of the mtDNA A1555G mutation in a large proportion of Chinese probands with nonsyndromic sensorineural hearing loss (NSHL) provides a molecular explanation for the high prevalence of aminoglycoside-induced deafness in China. OBJECTIVE: The aim was to...
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