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Article

CD4+ T cells from HIV-1-infected patients recognize wild-type and mutant human immunodeficiency virus-1 protease epitopes.

Clinical and experimental immunology - 1 Apr 2011

Muller N G, Alencar R, Jamal L, Hammer J, Sidney J, Sette A, Brindeiro R M, Kalil J, Cunha-Neto E, Moraes S L

Abstract excerpt

Human immunodeficiency virus (HIV)-1 protease is a known target of CD8+ T cell responses, but it is the only HIV-1 protein in which no fully characterized HIV-1 protease CD4 epitopes have been identified to date. We investigated the recognition of HIV-1 protease by CD4+ T cells from 75 HIV-1-infected, protease inhibitor (PI)-treated patients, using the 5,6-carboxyfluorescein diacetate succinimidyl ester-based...

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Identifiers

PMID: 21352200
DOI: 10.1111/j.1365-2249.2011.04319.x
PMCID: PMC3074221

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