Article
Functional interaction between human papillomavirus type 18 E2 and poly(ADP-ribose) polymerase 1.
Oncogene - 29 Aug 2002
Lee Daeyoup, Kim Jin Woo, Kim Karam, Joe Cheol O, Schreiber Valérie, Ménissier-De Murcia Josiane, Choe Joonho
Abstract excerpt
Human papillomavirus E2 protein is a transcription factor of viral gene expression and DNA replication. Here we show that PARP is a positive regulator of the E2 protein of human papillomavirus type 18 (HPV-18). PARP interacted with the COOH terminal region of HPV-18 E2 in vitro. The E2 interaction domain within PARP is located in the NH(2)-terminal zinc finger motif and the BRCT motif included in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
