Article
An improved solution structure for psi-conotoxin PiiiE.
Biochemistry - 3 Jun 2003
Van Wagoner Ryan M, Ireland Chris M
Abstract excerpt
A revised, high-resolution structure of psi-conotoxin Piiie (psi-Piiie), a noncompetitive inhibitor of the nicotinic acetylcholine receptor (nAChR), produced through the use of NMR and molecular modeling calculations is presented. The original structures of psi-Piiie had a relatively high degree of disorder, particularly in the conformation of the disulfide bridges. Our studies utilized (13)C-labeling of selected...
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