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Article

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.

Oncogene - 18 Dec 2003

Dow Lukas E, Brumby Anthony M, Muratore Rosa, Coombe Michelle L, Sedelies Karin A, Trapani Joseph A, Russell Sarah M, Richardson Helena E, Humbert Patrick O

Abstract excerpt

Scribble (scrib), discs large (dlg) and lethal giant larvae (lgl) encode proteins that regulate cell polarity and have been identified as neoplastic tumour suppressor genes in Drosophila melanogaster. Here, we have used the Drosophila model system to provide the first functional evidence that human Scribble (hScrib) can act as a tumour suppressor. We show that hScrib protein displays highly polarized localization...

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Identifiers

PMID: 14681682
DOI: 10.1038/sj.onc.1207154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.PMID 14681682Read ↗

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Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein LigaseSemantic proximity Read ↗

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.Semantic proximity Read ↗

Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.Semantic proximity Read ↗

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.Semantic proximity Read ↗

Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.Semantic proximity Read ↗

SCRIB Promotes Proliferation and Metastasis by Targeting Hippo/YAP Signalling in Colorectal CancerSemantic proximity Read ↗

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