Shared HLA class II-associated genetic susceptibility and resistance, related to the HLA-DQB1 gene, in IgA deficiency and common variable immunodeficiency.

doi:10.1073/pnas.89.22.10653

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Article

Shared HLA class II-associated genetic susceptibility and resistance, related to the HLA-DQB1 gene, in IgA deficiency and common variable immunodeficiency.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992

Olerup O, Smith C I, Björkander J, Hammarström L

Abstract excerpt

Most cases of selective IgA deficiency (IgA-D) and common variable immunodeficiency (CVID) occur sporadically. However, familial clustering is not uncommon, and the two disorders can occur within the same family. We have previously described positive associations with three DR-DQ haplotypes as well as a strong negative association with DRw15,DQw6,Dw2 in IgA-D. Different amino acids at position 57 of the HLA-DQ...

Topics

Alleles
Complement C4a
Gene Deletion
Gene Frequency
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-D Antigens
HLA-DQ Antigens
HLA-DQ beta-Chains
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

IgA Deficiency

Immunity, Innate

Immunologic Deficiency Syndromes

Phenotype

Reference Values

Steroid 21-Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 1438261
DOI: 10.1073/pnas.89.22.10653
PMCID: PMC50399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1438261-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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