Article
A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease.
Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2009
Maetzler Walter, Michelis Joan, Tomiuk Juergen, Melms Arthur, Becker Clemens, Gasser Thomas, Schulte Claudia, Berg Daniela
Abstract excerpt
In Lewy body disease, inflammation is discussed to be involved in the pathophysiological cascade. Osteopontin (OPN) is a multifunctional molecule, which is increased in inflammatory states. Here, we analyzed the allele frequency of two SNPs of the OPN gene, serum, and CSF OPN levels in Lewy body disease patients and controls. In accordance with our previous findings, we detected increased serum (P = 0.006) and...
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