Article
Genotyping of p53 codon 175 in colorectal cancer.
Medical science monitor : international medical journal of experimental and clinical research - 1 May 2003
Krajewska Wanda M, Stawińska Magdalena, Bryś Magdalena, Młynarski Wojciech, Witas Henryk W, Okruszek Andrzej, Kiliańska Zofia M
Abstract excerpt
BACKGROUND: The gene encoding the tumor suppressor protein p53 is one of the most frequently mutated in human cancer. Over 8000 mutations of this gene have been identified. The spectrum of p53 mutations varies among tumor types. More than half of these mutations appear in three hotspot codons: 175, 248 and 273. The purpose of the present study was to evaluate the GgA transition in codon 175 of the p53 gene as a...
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