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Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells.

Infection and immunity - 1 Jun 2003

Kim Suk, Watarai Masahisa, Kondo Yuki, Erdenebaatar Janchivdorj, Makino Sou-ichi, Shirahata Toshikazu

Abstract excerpt

Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and nonprofessional phagocytes and cause abortion in domestic animals and undulant fever in humans. The mechanism and factors of virulence are not fully understood. To identify genes related to internalization and multiplication in host cells, Brucella abortus was mutagenized by mini-Tn5Km2...

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Identifiers

PMID: 12761078
DOI: 10.1128/IAI.71.6.3020-3027.2003
PMCID: PMC155700

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Source receipt: pubmed, retrieved 7 Sept 2026.

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