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Article

Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

21 May 2003

Abstract excerpt

Schwann cells lacking the tumor-suppressor-protein merlin tend in man to build benign tumors (schwannoma). We observed that characteristic features of these cells which are relevant to tumorigenicity resemble those described in cells with high Rac activity. Moreover this small GTPase also phosphorylates merlin via PAK activation. We hypothesized that merlin deficiency might cause an activation of Rac and its...

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PMID: 12761036
DOI: 10.1093/hmg/ddg146

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