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Article

p21-Activated Kinases Are Required for Transformation in a Cell-Based Model of Neurofibromatosis Type 2

2 Nov 2010

Abstract excerpt

BACKGROUND: NF2 is an autosomal dominant disease characterized by development of bilateral vestibular schwannomas and other benign tumors in central nervous system. Loss of the NF2 gene product, Merlin, leads to aberrant Schwann cell proliferation, motility, and survival, but the mechanisms by which this tumor suppressor functions remain unclear. One well-defined target of Merlin is the group I family of...

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PMID: 21072183
DOI: 10.1371/journal.pone.0013791

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p21-Activated Kinases Are Required for Transformation in a Cell-Based Model of Neurofibromatosis Type 2PMID 21072183Read ↗

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