Article
From gonocytes to testicular cancer: the role of impaired gonadal development.
Annals of the New York Academy of Sciences - 1 Dec 2007
Rajpert-de Meyts Ewa, Hoei-Hansen Christina E
Abstract excerpt
Testicular germ-cell tumors occur primarily in young individuals, and the tumors in this age group (seminomas or nonseminomas) are derived from a preinvasive precursor cell called carcinoma in situ (CIS) or intratubular germ-cell neoplasia. These tumors have been a growing problem, especially in highly developed industrialized countries. A hypothesis was put forward that CIS originates from arrested fetal germ...
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