Article
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.
Carcinogenesis - 1 Nov 2002
Yokoyama Akira, Kato Hoichi, Yokoyama Tetsuji, Tsujinaka Toshimasa, Muto Manabu, Omori Tai, Haneda Tatsumasa, Kumagai Yoshiya, Igaki Hiroyasu, Yokoyama Masako, Watanabe Hiroshi, Fukuda Haruhiko, Yoshimizu Haruko
Abstract excerpt
The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-2 (ADH2), ADH3, and glutathione S-transferase M1 (GSTM1) influence the metabolism of alcohol and other carcinogens. The ALDH2*1/2*2 genotype, which encodes inactive ALDH2, and ADH2*1/2*1, which encodes the low-ac...
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