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Article

p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways.

Free radical biology & medicine - 1 Jan 2009

Vitiello Peter F, Wu Yu-Chieh M, Staversky Rhonda J, O'Reilly Michael A

Abstract excerpt

Although it is well established that the cell cycle inhibitor p21 protects against genotoxic stress by preventing the replication of damaged DNA, recent studies have shown that the cytoplasmic form can also protect. It protects by delaying the loss of the antiapoptotic proteins Mcl-1 and Bcl-X(L); however, the mechanism of regulation is unknown. Utilizing hyperoxia as a model of chronic oxidative stress and DNA...

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Source

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Identifiers

PMID: 18948188
DOI: 10.1016/j.freeradbiomed.2008.09.022
PMCID: PMC2631574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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