Article
Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection.
Cell cycle (Georgetown, Tex.) - 1 Oct 2006
Bouzahzah Boumediene, Nagajyothi Fnu, Desruisseaux Mahalia S, Krishnamachary Mohan, Factor Stephen M, Cohen Alex W, Lisanti Michael P, Petkova Stefka B, Pestell Richard G, Wittner Murray, Mukherjee Shankar, Weiss Louis M, Jelicks Linda A, Albanese Chris, Tanowitz Herbert B
Abstract excerpt
The liver is an important target of Trypanosoma cruzi infection. Infection of CD-1 mice with T. cruzi (Brazil strain) resulted in parasitism of the liver, primarily in sinusoidal and Kupffer cells. Immunoblot analysis revealed activation of extra cellular signal-regulated kinase (ERK) during the acute and subacute period of infection, but p38 mitogen activated kinase (MAPK) and JNK were not activated. The...
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