Article
Construction and in vitro characterization of attenuated feline immunodeficiency virus long terminal repeat mutant viruses.
Journal of virology - 1 Jan 2001
Bigornia L, Lockridge K M, Sparger E E
Abstract excerpt
AP-1- and ATF-binding sites are cis-acting transcriptional elements within the U3 domain of the feline immunodeficiency virus (FIV) long terminal repeat (LTR) that serve as targets for cellular activation pathways and may regulate virus replication. We report that FIV LTR mutant proviruses encoding U3 deletions of the ATF-binding sequence exhibited restricted virus expression and replication in both feline...
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