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Article

Impact of genetic profiles on experimental studies: outbred versus wild rats.

Toxicology and applied pharmacology - 15 May 2003

Klöting Ingrid, Nitschke Cindy, van den Brandt Jens

Abstract excerpt

Most rats used in toxicological or pharmacological research are obtained from outbred stocks. It is assumed that they are characterized by a high degree of genetic heterogeneity, reflecting that of the human population. However, most outbred stocks available have been kept as restricted colonies over a long period of time, decreasing their genetic variability. Since it is unclear to what extent genetic...

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Identifiers

PMID: 12758061
DOI: 10.1016/s0041-008x(03)00099-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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