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Article

ApoE genotype-specific inhibition of apoptosis.

Journal of lipid research - 1 Aug 2003

DeKroon Robert M, Mihovilovic Mirta, Goodger Zoe V, Robinette Jennifer B, Sullivan Patrick M, Saunders Ann M, Strittmatter Warren J

Abstract excerpt

Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoproteins from other APOE genotypes, as measured by caspase 3/7 activity. Moreover, APOE4/4 VLDL antagonizes the antiapoptotic activity of HDL by a mechanism requiring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12754278
DOI: 10.1194/jlr.M300097-JLR200

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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