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Article

Aging is associated with a proapoptotic endothelial progenitor cell phenotype.

Journal of vascular research - 1 Jan 2011

Kushner Erich J, MacEneaney Owen J, Weil Brian R, Greiner Jared J, Stauffer Brian L, DeSouza Christopher A

Abstract excerpt

The aim of this study was to determine if aging is associated with enhanced endothelial progenitor cell (EPC) sensitivity to apoptosis. Cells with phenotypic EPC characteristics were isolated from healthy, nonobese young (age 25 ± 1 years) and older (61 ± 1 years) men. Intracellular active caspase-3 concentrations in response to staurosporine stimulation were approximately 35% higher (p < 0.05) in EPCs from older...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21625174
DOI: 10.1159/000324837
PMCID: PMC3121552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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