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Article

Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia.

Leukemia - 1 Dec 2008

Weinberg J B, Volkheimer A D, Mihovilovic M, Jiang N, Chen Y, Bond K, Moore J O, Gockerman J P, Diehl L F, de Castro C M, Rizzieri D A, Levesque M C, Dekroon R, Strittmatter W J

Abstract excerpt

Survival of chronic lymphocytic leukemia (CLL) cells requires sustained activation of the antiapoptotic PI-3-K/Akt pathway, and many therapies for CLL cause leukemia cell death by triggering apoptosis. Blood lipoprotein particles are either pro- or antiapoptotic. High-density lipoprotein particles are antiapoptotic through sphingosine-1-phosphate receptor 3-mediated activation of the PI-3-K/Akt pathway....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18784741
DOI: 10.1038/leu.2008.241

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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