Article
Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation.
American journal of physiology. Heart and circulatory physiology - 1 Aug 2011
Mitra Sona, Khaidakov Magomed, Lu Jingjun, Ayyadevara Srinivas, Szwedo Jackob, Wang Xian Wei, Chen Chien, Khaidakov Said, Kasula Srikanth Reddy, Stone Annjanette, Pogribny Igor, Mehta Jawahar L
Abstract excerpt
Oxidized LDL (ox-LDL) plays a critical role in atherogenesis, including apoptosis. As hypercholesterolemia causes epigenetic changes resulting in long-term phenotypic consequences, we hypothesized that repeated and continuous exposure to ox-LDL may alter the pattern of apoptosis in human umbilical vein endothelial cells (HUVECs). We also analyzed global and promoter-specific methylation of apoptosis-related...
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