Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of interferon alpha therapy on the catalytic domains of the polymerase gene and basal core promoter, precore and core regions of hepatitis B virus.

Journal of gastroenterology and hepatology - 1 Jun 2003

Chen Robert Yung Ming, Bowden Scott, Desmond Paul Vincent, Dean Jo, Locarnini Stephen A

Abstract excerpt

AIMS: The aim of the present study was to examine the catalytic domains of the polymerase gene, the basal core promoter and the precore and core regions of the hepatitis B virus (HBV) genome for specific mutations. These may account for the response to interferon alpha (IFN-alpha) treatment, which may have prognostic value. METHODS: Multiple serum samples were collected prospectively from 30 patients with chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Terminator
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B Core Antigens

Share to Hepatitis B e Antigens

Share to Hepatitis B Surface Antigens

Share to Lamivudine

Share to Statistics as Topic

Share to Viral Core Proteins

Source

Identifiers

PMID: 12753143
DOI: 10.1046/j.1440-1746.2003.03019.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of interferon alpha therapy on the catalytic domains of the polymerase gene and basal core promoter, precore and core regions of hepatitis B virus.PMID 12753143Read ↗

Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis BSemantic proximity Read ↗

Relationship between HBV genotypes and anti-viral therapeutic efficacy of interferon-alpha.Semantic proximity Read ↗

Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversionSemantic proximity Read ↗

Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot studySemantic proximity Read ↗

Mutation Changes in the preC/Core Promoter in HBeAg-Positive Patients With Chronic Hepatitis B During Interferon Therapy.Semantic proximity Read ↗

Interferon Therapy of Chronic Hepatitis BSemantic proximity Read ↗

Genetic characteristics of hepatitis B virus genotypes as a factor for interferon-induced HBeAg clearance.Semantic proximity Read ↗

Hepatitis B genotypes and the response to interferon therapy.Semantic proximity Read ↗

Low HBeAg serum levels correlate with the presence of the double A1762T/G1764A core promoter mutation and a positive response to interferon in patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot studySemantic proximity Read ↗

Genomic variations in precore and cytotoxic T lymphocyte regions in chronic hepatitis B in relationship to interferon responsiveness.Semantic proximity Read ↗

Genomic variations in the hepatitis B core gene: a possible factor influencing response to interferon alfa treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.