Article
Genetic characteristics of hepatitis B virus genotypes as a factor for interferon-induced HBeAg clearance.
Journal of medical virology - 1 Aug 2007
Hou Jinlin, Schilling Ralf, Janssen Harry L A, Hansen Bettina E, Heijtink Rudolf, Sablon Erwin, Williams Roger, Lau George K K, Schalm Solko W, Naoumov Nikolai V
Abstract excerpt
The factors determining the responsiveness of different hepatitis B virus (HBV) genotypes to interferon treatment are not fully understood. We investigated the relationship between HBV genetic characteristics and the outcome of short (16 weeks) or prolonged (32 weeks) treatment with standard interferon-alpha in a prospectively followed cohort of 103 patients across Europe with HBeAg positive chronic hepatitis B....
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