Article
Asymptomatic carriership of factor V Leiden and genotypes of the fibrinogen gene cluster.
British journal of haematology - 1 May 2003
Marchetti Giovanna, Ferraresi Paolo, Legnani Cristina, Pinotti Mirko, Lunghi Barbara, Scapoli Chiara, Gemmati Donato, Coccheri Sergio, Palareti Gualtiero, Bernardi Francesco
Abstract excerpt
We investigated the role of frequent fibrinogen polymorphisms in venous thromboembolic disease in conjunction with inherited thrombophilia. Two hundred unrelated subjects, all carriers of the factor V R506Q mutation (FV Leiden), were genotyped at the fibrinogen gene cluster. Among these subjects, 100 had experienced previous venous thromboembolism (VTE) and 100 were still asymptomatic for VTE. Significant...
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