Article
Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy.
European journal of cancer (Oxford, England : 1990) - 1 Mar 2003
Aas T, Geisler S, Eide G E, Haugen D F, Varhaug J E, Bassøe A M, Thorsen T, Berntsen H, Børresen-Dale A L, Akslen L A, Lønning P E
Abstract excerpt
We previously reported that defects in apoptotic pathways (mutations in the TP53 gene) predicted resistance to doxorubicin monotherapy. The aim of this study was to evaluate whether cell proliferation, as assessed by mitotic frequency and Ki-67 levels, may provide additional predictive information in the same tumours and to assess any potential correlations between these markers and mutations in the TP53 gene and...
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