Article
[Proliferative activity and defective replication in breast cancer].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1994
Kreipe H, Zeidler R, Kneitz H, Feist H
Abstract excerpt
The highly proliferating phenotype of mammary carcinoma is known to be associated with a particularly aggressive clinical course. We have been interested in the underlying molecular causes that give rise to the increased proliferative activity Proliferative activity was determined immunohistochemically by the detection of topoisomerase II-alpha (Ki-S1). The subgroup of highly proliferating tumors with a Ki-S1...
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