Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat.

Physiological genomics - 7 Jul 2003

Coulter Ann Allen, Bearden Christie M, Liu Xiaotuan, Koza Robert A, Kozak Leslie P

Abstract excerpt

To identify novel regulatory factors controlling induction of the brown adipocyte-specific mitochondrial uncoupling protein (Ucp1) mRNA in the retroperitoneal white fat depot, we previously mapped quantitative trait loci (QTLs) that control this trait to chromosomes 2, 3, 8, and 19. Since the peroxisome proliferator activator receptor-gamma coactivator-1alpha (PGC-1alpha) regulates Ucp1 and other genes of energy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue, Brown

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dietary Fats

Share to Energy Metabolism

Share to Ion Channels

Share to Mice, Inbred A

Share to Mitochondrial Proteins

Share to Uncoupling Protein 1

Source

Identifiers

PMID: 12746468
DOI: 10.1152/physiolgenomics.00057.2003

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat.PMID 12746468Read ↗

Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue.Semantic proximity Read ↗

The Genetics of Brown Adipocyte Induction in White Fat DepotsSemantic proximity Read ↗

Transcriptional Synergy and the Regulation of <i>Ucp1</i> during Brown Adipocyte Induction in White Fat DepotsSemantic proximity Read ↗

Quantitative trait Loci for regional adiposity in mouse lines divergently selected for food intake.Semantic proximity Read ↗

Targeting PPARγ in the epigenome rescues genetic metabolic defects in miceSemantic proximity Read ↗

Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus.Semantic proximity Read ↗

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.Semantic proximity Read ↗

Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissueSemantic proximity Read ↗

Transcriptional Regulation of the Mouse Uncoupling Protein-2 GeneSemantic proximity Read ↗

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.Semantic proximity Read ↗

Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat.Semantic proximity Read ↗

C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.