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Article

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

13 Nov 2015

Abstract excerpt

Alzheimer's disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since neuroinflammation is thought to play an important role in AD, we hypothesized that cytokines may play a direct role in promoting neuronal death. Here, we profiled cytokine expression in a small cohort...

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PMID: 26564777
DOI: 10.1038/srep16622

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