Article
Apolipoprotein A-II, genetic variation on chromosome 1q21-q24, and disease susceptibility.
Current opinion in lipidology - 1 Jun 2004
Martín-Campos Jesús M, Escolà-Gil Joan Carles, Ribas Vicent, Blanco-Vaca Francisco
Abstract excerpt
PURPOSE OF REVIEW: Apolipoprotein (apo) A-II is the second most abundant HDL apolipoprotein; however its function remains largely unknown. Owing to the lack of consequences of apoA-II deficiency in humans, it has long been considered an apolipoprotein of minor importance. Overexpression of apoA-II in transgenic mice, however, causes combined hyperlipidemia and, in some cases, insulin resistance. This, and the...
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