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Article

Risk stratification in the long-QT syndrome.

The New England journal of medicine - 8 May 2003

Priori Silvia G, Schwartz Peter J, Napolitano Carlo, Bloise Raffaella, Ronchetti Elena, Grillo Massimiliano, Vicentini Alessandro, Spazzolini Carla, Nastoli Janni, Bottelli Georgia, Folli Roberta, Cappelletti Donata

Abstract excerpt

BACKGROUND: Mutations in potassium-channel genes KCNQ1 (LQT1 locus) and KCNH2 (LQT2 locus) and the sodium-channel gene SCN5A (LQT3 locus) are the most common causes of the long-QT syndrome. We stratified risk according to the genotype, in conjunction with other clinical variables such as sex and the length of the QT interval. METHODS: We evaluated 647 patients (386 with a mutation at the LQT1 locus, 206 with a...

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Source

Identifiers

PMID: 12736279
DOI: 10.1056/NEJMoa022147

Genes

KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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