Article
Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome.
Heart rhythm - 1 Oct 2011
Migdalovich Dimitry, Moss Arthur J, Lopes Coeli M, Costa Jason, Ouellet Gregory, Barsheshet Alon, McNitt Scott, Polonsky Slava, Robinson Jennifer L, Zareba Wojciech, Ackerman Michael J, Benhorin Jesaia, Kaufman Elizabeth S, Platonov Pyotr G, Shimizu Wataru, Towbin Jeffrey A, Vincent G Michael, Wilde Arthur A M, Goldenberg Ilan
Abstract excerpt
BACKGROUND: Men and women with type 2 long QT syndrome (LQT2) exhibit time-dependent differences in the risk for cardiac events. We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2. OBJECTIVE: This study sought to risk-stratify LQT2 patients for life-threatening cardiac events based on clinical and genetic information....
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