Article
Influence of the genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group.
The New England journal of medicine - 1 Oct 1998
Zareba W, Moss A J, Schwartz P J, Vincent G M, Robinson J L, Priori S G, Benhorin J, Locati E H, Towbin J A, Keating M T, Lehmann M H, Hall W J
Abstract excerpt
BACKGROUND: The congenital long-QT syndrome, caused by mutations in cardiac potassium-channel genes (KVLQT1 at the LQT1 locus and HERG at the LQT2 locus) and the sodium-channel gene (SCN5A at the LQT3 locus), has distinct repolarization patterns on electrocardiography, but it is not known whether the genotype influences the clinical course of the disease. METHODS: We determined the genotypes of 541 of 1378...
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