Article
Interplay Between Genetic Substrate, QTc Duration, and Arrhythmia Risk in Patients With Long QT Syndrome.
Journal of the American College of Cardiology - 17 Apr 2018
Mazzanti Andrea, Maragna Riccardo, Vacanti Gaetano, Monteforte Nicola, Bloise Raffaella, Marino Maira, Braghieri Lorenzo, Gambelli Patrick, Memmi Mirella, Pagan Eleonora, Morini Massimo, Malovini Alberto, Ortiz Martin, Sacilotto Luciana, Bellazzi Riccardo, Monserrat Lorenzo, Napolitano Carlo, Bagnardi Vincenzo, Priori Silvia G
Abstract excerpt
BACKGROUND: Long QT syndrome (LQTS) is a common inheritable arrhythmogenic disorder, often secondary to mutations in the KCNQ1, KCNH2, and SCN5A genes. The disease is characterized by a prolonged ventricular repolarization (QTc interval) that confers susceptibility to life-threatening arrhythmic events (LAEs). OBJECTIVES: This study sought to create an evidence-based risk stratification scheme to personalize the...
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