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Article

Dominant-negative cAMP-responsive element-binding protein inhibits proliferating cell nuclear antigen and DNA repair, leading to increased cellular radiosensitivity.

The Journal of biological chemistry - 8 Aug 2003

Amorino George P, Mikkelsen Ross B, Valerie Kristoffer, Schmidt-Ullrich Rupert K

Abstract excerpt

Selective inhibition of the epidermal growth factor receptor or mitogen-activated protein kinase (MAPK) results in radiosensitization of cancer cells. One potential mechanism involves cAMP-responsive element-binding protein, which is activated by radiation via the epidermal growth factor receptor/MAPK pathway and which regulates synthesis of proliferating cell nuclear antigen (PCNA), a protein involved in repair...

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Source

Identifiers

PMID: 12734192
DOI: 10.1074/jbc.M304012200

Genes

PCNA
CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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