The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis.

doi:10.1016/s0021-9150(03)00091-1

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Article

The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis.

Atherosclerosis - 1 May 2003

Kakko Sakari, Päivänsalo Markku, Koistinen Pirjo, Kesäniemi Y Antero, Kinnula Vuokko L, Savolainen Markku J

Abstract excerpt

Redox-state of the cells of vascular walls is an important determinant of atherosclerosis. Manganese superoxide dismutase (MnSOD) is an essential anti-oxidant enzyme working in mitochondria of mammalian cells. A potentially functional amino acid polymorphism (Ala16Val) has been described in the signal sequence of the enzyme. The aim of the current study was to test whether the signal sequence polymorphism of the...

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PMID: 12732398
DOI: 10.1016/s0021-9150(03)00091-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.