Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Throughput Screening for Neurodegeneration and Complex Disease Phenotypes

1 Mar 2008

Abstract excerpt

High throughput screening (HTS) for complex diseases is challenging. This stems from the fact that complex phenotypes are difficult to adapt to rapid, high throughput assays. We describe the recent development of high throughput and high-content screens (HCS) for neurodegenerative diseases, with a focus on inherited neurodegenerative disorders, such as Huntington's disease. We describe, among others, HTS assays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Image Analysis Techniques
Share to Genetic Neurodegenerative Diseases
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18336216
DOI: 10.2174/138620708783877753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Throughput Screening for Neurodegeneration and Complex Disease PhenotypesPMID 18336216Read ↗

Cell death assays for neurodegenerative disease drug discoverySemantic proximity Read ↗

TDP-43 high throughput screening analyses in neurodegeneration: Advantages and pitfallsSemantic proximity Read ↗

Phenotypic screens targeting neurodegenerative diseases.Semantic proximity Read ↗

Elucidating the Biochemical Role of Novel Enzyme Targets in Neurodegenerative DisordersSemantic proximity Read ↗

Neurodegenerative disorders of protein aggregationSemantic proximity Read ↗

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasisSemantic proximity Read ↗

Amyloid diseases: abnormal protein aggregation in neurodegeneration.Semantic proximity Read ↗

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read ↗

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegenerationSemantic proximity Read ↗

High throughput quantification of mutant huntingtin aggregates.Semantic proximity Read ↗

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neuronsSemantic proximity Read ↗

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.