Article
Development of a genotype 325-specific proCPU/TAFI ELISA.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2003
Gils Ann, Alessi Marie-Christine, Brouwers Els, Peeters Miet, Marx Pauline, Leurs Judith, Bouma Bonno, Hendriks Dirk, Juhan-Vague Irène, Declerck Paul J
Abstract excerpt
OBJECTIVE: A Thr/Ile polymorphism at position 325 in the coding region of proCPU has been reported. Immunological assays, fully characterized (including genotype dependency), are required for the quantitation of proCPU levels. METHODS AND RESULTS: We have generated a panel of monoclonal antibodies against human, plasma-derived proCPU. Two combinations exhibiting distinct reactivities were selected for measurement...
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