Article
Quantification of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism effects on plasma levels of TAFI measured with assays insensitive to isoform-dependent artefact.
Thrombosis and haemostasis - 1 Aug 2005
Frère Corinne, Morange Pierre Emmanuel, Saut Noémie, Tregouet David Alexandre, Grosley Mariana, Beltran Jérôme, Juhan-Vague Irène, Alessi Marie-Christine
Abstract excerpt
Reports have reappraised the genotype-dependent variation of Thrombin Activatable Fibrinolysis Inhibitor (TAFI), demonstrating that, in some enzyme-linked immunosorbent assays (ELISA), decreased antibody reactivity towards the TAFI 325 Ile isoform led to erroneous TAFI levels. Assays free of this artefact are required to evaluate the contribution of the TAFI gene polymorphisms to TAFI level variability. TAFI...
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