Article
Genetic modulation of plasma protein S levels by two frequent dimorphisms in the PROS1 gene.
Thrombosis and haemostasis - 1 Sept 1999
Leroy-Matheron C, Duchemin J, Levent M, Gouault-Heilmann M
Abstract excerpt
We studied two polymorphisms located close to or within the 3'-untranslated (3'-UT) region of the PROS1 gene [an A to G transition at nt 2148 (Pro 626) and an A to C substitution at nt 2698] in 110 healthy volunteers. The allele frequency of the nt 2148 G variant was 35%, and that of the nt 2698 A variant was 27%. We found a relationship between the two dimorphisms (both separately and together) and the plasma...
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