Development of a monoclonal antibody capable of differentiating platelet PLA1/PLA1, PLA1/PLA2 and PLA2/PLA2 genotypes.

doi:10.1111/j.1365-2141.1992.tb08182.x

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Article

Development of a monoclonal antibody capable of differentiating platelet PLA1/PLA1, PLA1/PLA2 and PLA2/PLA2 genotypes.

British journal of haematology - 1 May 1992

Liu L X, Nardi M, Flug F, Karpatkin S

Abstract excerpt

A monoclonal antibody, LK-4, has been developed which distinguishes platelet PLA1/PLA1, PLA1/PLA2 and PLA2/PLA2 genotypes on platelet glycoprotein GPIIIa of Triton-solubilized platelet extracts. An ELISA assay has been developed which traps GPIIIa with Concanavalin A, enriching the platelet extra...

Topics

Alleles
Antibodies, Monoclonal
Antigens, Human Platelet
Enzyme-Linked Immunosorbent Assay
Female
Genotype
Heterozygote
Homozygote
Humans
Immunoblotting
Platelet Membrane Glycoproteins
Pregnancy
Purpura, Thrombocytopenic

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