Article
Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells.
PloS one - 1 Jan 2013
Liu Lanlan, Yang Zhaojuan, Xu Yingqian, Li Jingyi, Xu Dongxu, Zhang Li, Sun Jiabin, Xia Suhua, Zou Feiyan, Liu Yongzhong
Abstract excerpt
Emerging evidence suggests that tumor-initiating cells (TICs) are the most malignant cell subpopulation in tumors because of their resistance to chemotherapy or radiation treatment. Targeting TICs may be a key innovation for cancer treatment. In this study, we found that PPARγ agonists inhibited the cancer stem cell-like phenotype and attenuated tumor growth of human hepatocellular carcinoma (HCC) cells. Reactive...
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