Article
Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the Notch signals in differentiation.
Biochemical and biophysical research communications - 16 May 2003
Okumoto Kazuo, Saito Takafumi, Hattori Etsuko, Ito Jun-itsu, Adachi Tohru, Takeda Tadashi, Sugahara Kazuhiko, Watanabe Hisayoshi, Saito Koji, Togashi Hitoshi, Kawata Sumio
Abstract excerpt
Bone marrow (BM) stem cells have been shown to differentiate into liver cells. It remains difficult to sort and culture BM stem cells, and the gene expression of liver-specific proteins in these cells has not been fully investigated. We used a negative selective magnetic cell separation system to obtain stem cell-enriched BM cells. The cells obtained were cultured with hepatocytes or with hepatocyte growth factor...
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