Article
New insights into chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712.
Antimicrobial agents and chemotherapy - 1 Dec 2014
Fernández-Martínez Lorena T, Borsetto Chiara, Gomez-Escribano Juan Pablo, Bibb Maureen J, Al-Bassam Mahmoud M, Chandra Govind, Bibb Mervyn J
Abstract excerpt
Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol. Transcriptional analysis suggested that three of these genes might be involved in...
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